Heat-inactivated mycobacteria as immunogens in ruminants: route of administration, host response and diagnosis

  • Financing: MINECO (Ministry of Economy and Competitiveness) AGL2014-56305-C3
  • Head researcher: Joseba Garrido
  • Implementation: 2015-2018

The general objective of this project is to determine the effect of the application of immunostimulants in the control of tuberculosis in cattle and deer. Confirmation of the results observed in wild boar.
The specific objectives are:

1. To find out the response of ruminants (cattle and deer models) to oral immunostimulation (IS) and subsequent challenge with M. bovis (under BSL3 conditions), compared to oral BCG and placebo controls.
2. To analyse the response of farm deer to oral IS and inactivated oral MAP (Mycobacterium avium subsp. paratuberculosis), and the response of wild deer to the former under field conditions.
3. To assess the effect of oral IS on the results of the in-vivo diagnostic tests on the two species in laboratory and field situations