Bacteria-host interactions in infections with Mycobacterium avium subsp. paratuberculosis (MAP): Susceptibility of domestic ruminants to infection with different MAP genotypes

  • Financing: INIA (National Institute for Agricultural and Food Research and Technology) RTA2011-00049-00-00
  • Head researcher: Marta Alonso
  • Implementation: 2011-2014

The overall objective of the project is to compare the virulence of isolated strains of Mycobacterium avium subsp. paratuberculosis (MAP) from different hosts and geographical locations by analysing their entry and survival in cattle, sheep and goat macrophages; and by the study of induced immune responses in these cell models.

The specific objectives and tasks are:

1. To evaluate the intracellular entry, multiplication and survival of MAP strains from different genotypes, geographical locations and hosts in macrophages of the domestic ruminants most commonly infected with MAP (sheep, goats and cattle).
2. To determine the immune response in macrophages of domestic ruminants against an infection with selected strains of MAP.